NSAID drugs constitute the 15th most common cause of death in the United States N Engl J Med. 2006 (10000 to 20,000 deaths due to NSAID-induced GI complications each year JAMA 1998)

NSAID’S inhibit tendon-to-bone healing  Am J Sports Med 2006

NSAID use Raises Risk of Erectile Dysfunction  J Urol 2006

Topical NSAID’S and intra-articular steroid injections offer no meaningful pain relief beyond the first month.  Euro J of Pain 2006

More than 70 percent of patients who took painkillers such as ibuprofen for more than three months suffered damage to their small intestines. Clinical Gastroenterology and Hepatology

COX-2 inhibitors can raise the risk of heart death Clinical Gastroenterology and Hepatology

Small-bowel injury was seen in 71 percent of NSAID users compared with 10 percent of control [group] Clinical Gastroenterology and Hepatology

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